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A new study by led by Children’s Hospital of Philadelphia (CHOP) has found that neighborhood violent crime is associated with high levels of perceived stress in pregnancy. The study, published in the International Journal of Environmental Research and Public Health, also found that even though the results held up regardless of race, Black women were significantly more likely to live in neighborhoods with high levels of violent crime and were more likely to report high perceived stress than non-Black women.
A team of researchers at Children’s Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) further bridged the gap between genomic information and clinical outcome data by systematically linking genetic information with electronic medical records, focusing on how genetic neurological disorders in children develop over time. The findings were published today in the journal Genetics in Medicine.
More than three-quarters of the patients in Penn State Health Milton S. Hershey Medical Center’s Cardiac Rehabilitation Program find their depression decreases, half of patients see their strength nearly doubled and 80% of patients meet their blood pressure goal of 130/80 or lower.
According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells. These messages are packaged into particles called extracellular vesicles (EVs) and reprogram mitochondrial shape and position within the recipient normal cells to ultimately promote deregulated tissue morphogenesis. These findings were published today in Developmental Cell.
Dr. Maureen Murphy, Ira Brind Professor and program leader of the Molecular & Cellular Oncogenesis Program of The Wistar Institute Cancer Center, has been investigating the importance of inherited mutations in the gene encoding p53 tumor suppressor protein to determine cancer susceptibility in people of African descent and people of Ashkenazi Jewish descent, for the past twenty-two years.
Women carrying twins are at higher risk for premature birth and miscarriage – those whose cervix dilates before 24 weeks are at highest risk – and yet one common treatment is not recommended for this population. A new multi-center randomized-controlled trial from Thomas Jefferson University shows that cerclage, an intervention that sutures a dilating cervix closed, can help prevent preterm birth and miscarriage. The findings could overturn existing guidelines.
Studies have shown that intrauterine devices (IUDs) that release progestins can help adult women with heavy menstrual bleeding, discomfort, and cramping, in addition to providing contraception. However, there are little data on whether they reduce these symptoms in younger women and adolescents, especially those with physical or intellectual disabilities. New research from the largest dataset studied to date, demonstrates that IUDs are an effective means of stopping periods or managing symptoms associated with periods in adolescents with disabilities.
Patients with obesity are at higher risk of developing heart failure. And yet, many obese patients face obstacles to getting heart transplants, as recovery is considered to be more challenging and risky in individuals with high body mass. Some physicians have attempted to pair bariatric surgery, which has shown to effectively reduce body mass in some patients, with LVAD surgery – considered a bridge to heart transplantation. However, the studies in general were too small to assess whether the approach was generalizable. New research from Jefferson pooled and analyzed data from multiple studies in a meta-analysis to assess the real-life impact of pairing the bridge-to-transplant LVAD surgery with a sleeve gastrectomy, a bariatric procedure for morbidly obese patients performed for weight reduction.
Amid the COVID-19 pandemic, many researchers are trying to determine which vulnerable populations are at risk of contracting the virus. Pregnant women are among those most vulnerable because the virus could put both the mother and newborn at risk.
In the early days of the COVID-19 pandemic, the SARS-CoV-2 virus seemed only rarely to have serious complications in children. However, by April 2020, pediatricians had begun recognizing a syndrome in children who tested positive for COVID-19 involving hyperinflammation and some other attributes found in Kawasaki disease (KD). By May, the Centers for Disease Control and Prevention (CDC) had named the new condition Multisystem Inflammatory Syndrome in Children (MIS-C). Yet the biology of MIS-C and how it relates to or differs from severe COVID-19 in children has largely remained a mystery.
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